A.P. Bio, Mike O’Brien’s high school comedy, returns for its second season next Thursday, March 7. In honor of the new season, we sat down with the cast, crew, and creators of the show for a series of interviews. Today, Patton Oswalt talks about coming back to Whitlock High for season two, and why Paula Pell—who plays his loyal assistant Helen—is the funniest person on TV.

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