Despite being diagnosed with “overexposure” in a previous teaser, Amy Schumer is ignoring her TV doctor’s orders to go into seclusion, and is instead preparing for season four of her Comedy Central series. The first full trailer for Inside Amy Schumer was released today, and it looks like the actress-comedian will wade into the presidential race, but only to demonstrate that a woman can’t be Commander-In-Chief because of menstruation. Along with Missi Pyle (who was bound to show up, because she’s been in practically everything else) and Amber Tamblyn, Schumer will dive into familiar territory with vagina jokes, sex jokes, and whatever breaks up that Lamaze class. The minute-and-a-half trailer moves at a breakneck pace, but you should be able to catch the Hamilton and Game Of Thrones references.

Season four of Inside Amy Schumer premieres April 21 on Comedy Central.